Fire in the Knee
Biomedical Engineering / Graduate Student
Polarized Light Microscopy (20x)
Shown is 5 uM thick paraffin-embedded section of a normal mouse knee joint, specifically the medial compartment meniscus, femoral condyle, and tibial plateau, that was stained with picrosirius red. This stain takes advantage of the birefringence property of collagen fibers (all types of collagen fibers refract light) to visualize the collagen organization and presence in the articular cartilage, subchondral bone, and meniscus, which creates an appearance of fire in the mouse knee joint.
Fire in the Knee2018, Art in Science